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But, there clearly was presently no chance to prospectively evaluate anti-oxidant defenses in humans. Tin protoporphyrin (SnPP) causes mild, transient oxidant stress in mice, causing increased phrase of select antioxidant proteins (e.g., heme oxygenase 1 [HO-1], NAD[P]H dehydrogenase [quinone] 1 [NQO1], ferritin, p21). Ergo, we tested the hypothesis that SnPP also can variably boost these proteins in humans and that can therefore act as a pharmacologic "stress test" for gauging gene responsiveness and an