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Significantly more IL-17 immune cells (CD45 IL17 ) are present in the gingiva of Il1ra mice with the majority of being TCR γδ T cells (CD45 IL-17 CD3 TCR γδ ) than WT mice The anti-IL-17 neutralizing antibody treatment attenuated the alveolar bone loss in the LIP model. IL-1RA plays a protective role in the murine LIP model by suppressing an expansion of the IL-17 cells and preventing a hyper-IL-17 response in the gingiva. IL-1RA plays a protective role in the murine LIP model by suppressing an expansion of the IL-17+ cells and preventin
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