https://www.selleckchem.com/pr....oducts/ph-797804.htm
dicals, Inc.BACKGROUND Muscarinic receptor 1 positive allosteric modulators (M1PAMs) enhance colonic propulsive contractions and defecation through the facilitation of M1 receptor (M1R)-mediated signaling. We examined M1R expression in the colons of 5 species and compared colonic propulsion and defecation caused by the M1PAM, T440, the 5-HT4 agonist, prucalopride, and the cholinesterase inhibitor, neostigmine, in rats and dogs. METHODS M1R expression was profiled by immunostaining and in situ hybridization. In vivo studies utilized ma
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