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PRACTICES We performed a retrospective case series for which information had been shared by individual scientists, research networks and physicians worldwide as part of the RSV Global on the web Database research. We included children with DS whom died whenever younger than 5 years of age with laboratory-confirmed RSV infection. OUTCOMES We included 53 kiddies with DS and RSV-related mortality from 20 nations in 5 continents. Five (9.4%) children had been from low-income or lower-middle-inc