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Besides, the antitumor effect of connected CER with PD-L1 inhibitor in ALK-rearranged NSCLC aren't totally understood. In H2228 cells, we examined the cyst killing effectation of CER plus PD-L1 inhibitor in vitro by quantitative RT-PCR, flow cytometry, ELISA, western blotting, peripheral blood mononuclear cells (PBMC) co-culture system, plasmid and transfection experiments. Then, a Ba/F3 (EML4-ALK-WT) xenograft mice design ended up being used to further evaluate the synergistic anticanc