https://www.selleckchem.com/pr....oducts/cbr-470-1.htm
miR-27a augmentation via tail-vein injection of miR-27a mimic in high cholesterol diet-fed Apoe -/- mice shows down-regulation of hepatic Hmgcr and plasma cholesterol levels. Pathway and gene expression analyses show that miR-27a also targets several other genes (apart from Hmgcr) in cholesterol biosynthesis pathway. Taken together, miR-27a emerges as a key regulator of cholesterol biosynthesis and has therapeutic potential for clinical management of hypercholesterolemia. Copyright © 2020 American Society for Microbiology.Stress granu
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