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Nonetheless, WHIMP-mediated Arp2/3 activation improves both plasma membrane layer ruffling and wound recovery migration, whereas WHIMP depletion impairs protrusion and slows motility. WHIMP expression additionally increases Src-family kinase task, and WHIMP-induced ruffles retain the extra nucleation-promoting elements WAVE1, WAVE2, and N-WASP, however JMY or WASH. Perturbing the event of Src-family kinases, WAVE proteins, or Arp2/3 complex inhibits WHIMP-driven ruffling. These