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In addition, N45 decreased the drug-resistance by down-regulation of nuclear factor kappa-B p65 (NF-κB p65) to attenuate O6-methylguanine-DNA methyltransferase (MGMT) in TMZ-resistant glioblastoma cells (U87R). Our results proved that N45 could be a potential healing broker against glioblastoma and TMZ-resistant glioblastoma, promising become a potential agent to reduce medication weight.Various aerobic diseases is recognized and identified using echocardiography. The need for cardiovascula
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