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effective screening of the effects of I. paraguariensis bioactive substances. Balarista is a fermented ayurvedic liquid preparation recommended as a good therapy for the treatment of rheumatoid arthritis. In the present investigation, the anti-arthritic activity of in-house Balarista formulation and marketed M1, M2, M3 and M4 Balarista formulations at the dose of 2.31ml/kg were studied on Complete Freund's adjuvant-induced arthritic rat model. Measurement of paw diameter, arthritic index, arthritic score, and body weight were made to ass