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Conclusions Health professionals should be well-informed about psychosocial roles, either as facilitators or constraints, in older adults' physical activity participation. Incorporation of psychosocial intervention into physical activity promotion can help older adults develop positive attitudes and inner strength linked to their health behaviour. © The Author(s) 2020.Background In the Italian Breast Cancer Intergroup Studies (IBIS) 3 phase III trial, we compared cyclophosphamide, methotrexate, 5-fluorouracil (CMF) alone to sequential epir