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I read with interest the recent meta-analysis by Katsanos et al.(1) The authors are to be applauded for their efforts and careful analysis. In view of the potential significance of the findings, a trial sequential analysis (TSA) was performed to assess the conclusiveness of the presented evidence. This article is protected by copyright. All rights reserved.Transcutaneous vagus nerve stimulation (tVNS) is a non-invasive neurostimulation technique that is currently being tested as a potential treatment for a myriad of neurological and psych