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Among ctDNA-positive patients, ctDNA small fraction averaged just 3.9% and showed no powerful connection with medical variables. Within these customers, the absolute most generally mutated genetics had been VHL, BAP1, and PBRM1, and coordinated tissue concordance was 77%. Proof of somatic expansions unrelated to RCC, such as clonal hematopoiesis of indeterminate potential, were recognized in 43% of clients. Pathogenic germline mutations in DNA repair genes had been recognized
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