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We discovered that VCSCS present in the B16F10 cellular line reappearing in their clones were necessary for constant tumefaction growth and had been responsible for melanoma cellular heterogeneity and plasticity rather than straight impacting useful qualities of melanoma cells. Our information, as well as those of previous reports suggested the existence of melanoma-competent melanocyte stem cells, which corroborate the theory of this presence of tumor-initi
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