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The confluence of historical discovery, development of unbiased screening strategies, and the evolution of medicinal chemistry has allowed us to begin therapeutically targeting vulnerabilities that emerge due to pVHL loss in ccRCC. Ongoing mechanistic studies on the biological consequences of pVHL loss, therefore, are likely to become the cornerstones of modern therapeutics in renal cancer. INTRODUCTION Atrial Fibrillation (AF) is the most common cardiac arrhythmia in clinical practice and its prevalence rate significantly increases wit
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