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0001). The six IEQ items with the highest carer burden at baseline were within the urging and worrying domains, in which burden was significantly improved at LOCF endpoint (P0.0001). Exploratory analyses found that higher carer burden was associated with lower functional remission (Personal and Social Performance score7 at baseline and LOCF endpoint, and with the patient being part of the carer's household. Shorter disease duration correlated with better general health of carers at LOCF endpoint. Reducing the frequency of antip