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To investigate the association between night waking frequency in 3- to 4-month-old infants and mothers' response to them. Cross-sectional survey. We examined 663 mothers of infants aged 3-5months who attended regular health checks for 4months at 7 public health centres in Japan between September 2006 and March 2007. Mother-reported questionnaires were used, measuring the frequency of infants' night waking and four types of responses by mothers. Using multiple regression, the association between number of wakings and each response was