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More importantly, the therapeutic effects of rGDF11 on stroke had been consequently explored. The outcome in MCAO rats treated with rGDF11 were found similar to that in those addressed with all the GDF11 overexpression lentivirus. Collectively, these results suggest that GDF11 has actually neuroprotective and neurorestorative impacts in cerebral ischemic injury and provide new insights to the function and mechanism of GDF11 in stroke models. The
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