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Objectives Prediabetes is a major public health concern. Different plant extracts are used in homeopathy as mother tinctures (MTs) for the treatment of prediabetes as an adjunct to individualized homeopathic medicines (IHMs); however, their effectiveness remains under-researched. Design Open-label, randomized (11), active-controlled, pragmatic, exploratory trial. Setting Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India. Subjects Eighty-nine patients with prediabetes. Interventions Group 1 (n = 45