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Ribosomal Protein S4, Y-Linked 1 (RPS4Y1) was confirmed to manage the opposition of CD4+ T cells from male VKH clients to CsA CS. Importantly, we showed that chlorambucil (CL could reverse the opposition by RPS4Y1 suppression. Taken together, we identify RPS4Y1 as an important CsA CS resistance gene in VKH disease. Scientists should think about validating the resistant aftereffect of RPS4Y1 various other autoimmune diseases or organ transplantation. This