https://www.selleckchem.com/pr....oducts/gsk591-epz015
RESULTS A total of 67 patients were included in the study. The DAS28 after initiation of leflunomide was associated with baseline DAS28 (β=0.70, p less then 0.001) and was higher in those who carried DHODH Haplotype 2 (β=0.56, p=0.01) and did not carry the shared epitope (β=0.56, p=0.013). As total and free plasma teriflunomide concentration increased, DAS28 was significantly lower (p less then 0.001 and p=0.001 respectively). When considering threshold concentrations, teriflunomide concentrations above 16 mg/L were
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