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This study describes the solvent and catalyst-free Ugi reaction by way of twin screw extrusion (TSE). Multicomponent chemical synthesis can be converted into a single process without repeated use of solvents through TSE. High synthetic yields are achieved in short reaction times and produced in solvent-free conditions, which lead to a more environmentally friendly process. Copyright © 2020 American Chemical Society.This work reports for the first time the preparation and performance of a nanosensor for the simultaneous detection of meta
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