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Statement of the Problem Low pH of self-etch adhesives might cause suboptimal polymerization. Purpose This study aimed to evaluate the effect of dentin depth (deep and superficial) on polymerization efficacy of two self-etch adhesives, with different pH by means of Knoop hardness test. Materials and Method In this in vitro study, sixty sound molars were used to prepare 30 superficial dentin and 30 deep dentin specimens. Dentin specimens of each depth were randomly distributed into two equal subgroups (N=15) and bonded by either Adper Pr