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Intra- and inter-observer reliability were excellent (range 0.82-0.99). The range of the mean absolute difference of the intra- and inter-observer translational and rotational measurements were 0.14 mm (0.13)-0.44 mm (0.5 and 0.20° (0.16)-0.92° (0.78). The approach has excellent reliability for 3D assessment of long-term stability of segmental bimaxillary surgery. Limited data are available on the prognostic and predictive value of fibroblast growth factor receptor alterations (FGFRa) relative to clinical outcomes in patients with non-m