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This study examined the environmental performance of mussel (Mytilus galloprovincialis) farming in the view of reduction of greenhouse gas emissions, through the Life Cycle Assessment (LCA) methodology. The LCA has been integrated with the evaluation of the carbon sequestration potential of the biocalcification process. Three case studies of mussel farming sited along the coastal area in the north Adriatic Sea, Italy, were analyzed. Two of them concerned mussels that do not require a depuration process (area Class A), and one inspected