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The remitters further showed significantly larger SampEn on the left frontal area at baseline, and this lateralization disappeared after antidepressant treatment except for the poor responders. This study was limited by a small sample size and without healthy controls. Homogeneity in frontal-central alpha complexity and interhemispheric asymmetry normalization of anterior EEG complexity are associated with antidepressant efficacy, suggesting that homogeneity of dynamical brain activity is a key linked to the successful treatment of major
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