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BACKGROUND The burden of non-invasive Group B Streptococcus (GBS) infections in adults is unknown. We determined population-based rates of hospitalization where invasive or non-invasive GBS infections were identified among US adults in a defined catchment area. METHODS We identified adults with clinical and laboratory-confirmed evidence of GBS infection from January 2014 through December 2016 from six hospitals in Louisville, Kentucky. Invasive disease was defined as GBS isolated from a normally sterile site. RESULTS Among 1076 adults with GBS infection, me