https://www.selleckchem.com/pr....oducts/alw-ii-41-27.
Although most experimentally characterized proteins with similar sequences assume the same folds and perform similar functions, an increasing number of exceptions is emerging. One class of exceptions comprises sequence-similar fold switchers, whose secondary structures shift from α-helix β-strand prediction discrepancies from JPred4 discriminated between the different conformations of sequence-similar fold switchers with high statistical significance (P less then 1.8*10-19 ). Thus, we used these discrepancies as a classifier and f
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