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With regards to geographical variation, cities had greater pharmaceutical levels than rural areas, that has been attributed to the former's large populace thickness and biggest wastewater treatment flowers (WWTPs) no matter period. The total concentration and recognition frequency of WWTPs were 12.4 and 2.5 times greater in downstream websites than upstream sites, therefore conveying that WWTPs were the main source when it comes to presence of pharmaceuticals in tributaries. In