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Furthermore, we unearthed that PD-L1 phrase in esophageal cancer tumors cells affected the antitumor function of CTLs. PD-1/PD-L1 blockade could increase the certain CTL-induced lysis of HLA-A2+/MAGE-A11+ cyst cellular lines addressed with 5-aza-2'-deoxycytidine. These conclusions suggest that the treating tumor cells because of the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine augments MAGE-A11 phrase in esophageal disease cells. The mixture of epigenetic modulation by 5-