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To study the efficacy of tandospirone citrate in treating Alzheimer's disease (AD) patients with anxiety. Thirty mild-to-moderate AD patients with anxiety symptoms were randomly divided into a monotherapy group (donepezil) and a combination therapy group (donepezil and tandospirone). The treatment lasted for 12 weeks. Drug efficacy was regularly assessed using psychological assessment scales and quantitative pharmaco-electroencephalogram (QPEEG) power spectral analysis. After 12 weeks of treatment, the mean Hamilton Anxiety Scale (HAMA) s