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Expert opinion More in-depth understanding of the role of angiogenesis factors and the relationship between angiogenesis and other aspects of the pathogenesis and transformation may be the key to enabling future progress in the treatment of patients with liver fibrosis, cirrhosis, and HCC.Introduction Patients with cholestatic diseases may develop fatigue and cognitive symptoms. #link# The impact of symptom burden may be significant in some patients. To date, there are no effective pharmacological therapies to improve cognitive symptom