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seminated through publication in a peer-reviewed journal. Since the data and results used in the systematic review will be extracted exclusively from published studies, approval from an ethics committee will not be required.Studies have obtained conflicting findings regarding the association between the interleukin-1β (IL-1β) +3954 CT polymorphism and the risk of sepsis. To evaluate the association between the IL-1β +3954 CT polymorphism and sepsis risk in Chinese individuals, we conducted a study of 254 sepsis patients and 322