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We have also discussed novel synthetic strategies developed during this period for the synthesis of different indole derivatives. We believe this review article will provide comprehensive knowledge about the medicinal importance of indoles and will help in the design and synthesis of novel indole-based molecules with high potency and efficacy. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Inflammatory bowel diseases, including both Crohn's disease and ulcerative colitis are two chronic and