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Copyright © 2020 Cui Hua Liu et al.Myocardial ischemic postconditioning- (IPo-) mediated cardioprotection against myocardial ischemia-reperfusion (IR) damage needs the activation of sign transducer and activator of transcription 3 (STAT3), that involves adiponectin (APN). APN confers its biological impacts through AMP-activated protein kinase- (AMPK-) dependent and AMPK-independent paths. Nonetheless, the role of AMPK in APN-mediated STAT3 activation in IPo cardioprotection