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001). On univariate analysis, predicting variables were as follows age at presentation 1 year (p 0.001), nadir serum creatinine 1 mg/dl (p 0.001), B/L high-grade VUR (p 0.001), severe bladder dysfunction (p 0.001), recurrent febrile UTIs (p = 0.002), polyuria (p 0.001), and polydipsia (p 0.001). On multivariate Cox regression analysis, severe bladder dysfunction, recurrent febrile UTIs, polyuria, and polydipsia were identified as significant prognostic factors predictive of ultimate progression to
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