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001). Multivariate analysis demonstrated that higher mGPS score was independently associated with poor OS and DFS (p0.001). The predictive accuracy of the mGPS was superior to other IBSs (all p0.001) in survival prediction in iCCA patients. The findings were further supported by the external validation cohort. The mGPS is a sensitive, efficient, simple and widely applicable preoperative prognostic factor for iCCA patients. Thus, more effective therapy and frequent surveillance should be conducted after surgical resection in iCCA p