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Our results showed a significant improvement in leg extension for both the exercise program alone and the combined groups ( 0.001). Nine genes showed significant pre- and post-difference in gene expression over 12 weeks of intervention in the combined group. Seven genes ( , , , , , , and ) showed an interaction effect between intervention and gene expression levels on leg extension in the confirmatory analysis, with confounder variables controlled and FDR correction. Our findings showed that T cell-specific inflammatory gene express
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