https://www.selleckchem.com/products/cpi-203.html
Transient or sustained permeability transition pore (PTP) opening is important in normal physiology or cell death, respectively. These are closely linked to Ca^2+ and reactive oxygen species (ROS). The entry of Ca^2+ into mitochondria regulates ROS production, and both Ca^2+ and ROS trigger PTP opening. In addition to this feedforward loop, there exist four feedback loops in the Ca^2+-ROS-PTP system. ROS promotes Ca^2+ entering (F1) and induces further ROS generation (F2), forming two positive feedback loops. PTP opening results in the
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