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https://www.selleckchem.com/pr....oducts/etomoxir-na-s
Simon's two-stage design is a widely used adaptive design, particularly in phase II oncology trialsdue to its simplicity and efficiency. However, its efficiency can be adversely affected when the primary end-point takes time to observe, as is common in practice. We propose an optimal design, taking the delay in observing treatment outcome into consideration and compare the efficiency gained from using Simon's design over a single-stage design for real-life oncology trials. Based on the results, we provide a general rule-of-thum