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Patients with PCOS without IR had lower TSP-1 levels than control patients (P 0·05). Treatment with cyproterone acetate/ethinyloestradiol with addition of metformin reduced the level of NF-κB, TGF-β1 and HOMA-IR and increased the level of TSP-1. These results support the association between PCOS and chronic inflammation. These results support the association between PCOS and chronic inflammation.The identification of patients at risk for sudden cardiac death (SCD) is still a significant challenge to clinicians and scientists. Noninv