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25). HT participants exhibited lower (p = 0.01) StO2 at decompensation compared to LT participants. Conclusions Lower StO2 measured in patients during low flow states associated with significant hemorrhage does not necessarily translate to a more compromised physiological state, but may reflect a greater resistance to the onset of shock. Only the CRM was able to distinguish between HT and LT participants early in the course of hemorrhage, supported by a significantly greater ROC AUC (0.9 compared with STO2 (0.68). These results suppor