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Copyright © 2020 Li, Ding, Jiang, Hayat, Song, Li, Zhang and Zhang.Identifying therapies that mitigate ischemic colonic damage and enhance mucosal recovery and intestinal viability are necessary to increasing success in horses with ≥360° big colon volvulus (LCV). Ethyl pyruvate is the ethyl ester of pyruvate with diverse pharmacologic effects that limit ischemic injury and hasten abdominal mucosal fix in preclinical rodents, sheep and swine designs. The aim of this research was to figure