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Laparoscopic distal pancreatectomy (LDP) is widely performed [1,2]. However, LDP with regional lymphadenectomy for locally advanced pancreatic cancer (LAPC) is technically demanding [3]. We previously reported a new strategy named "retroperitoneal-first laparoscopic approach (Retlap)" for distal pancreatectomy with en bloc celiac axis resection [4]. In this study, Retlap is applied during LDP with regional lymphadenectomy (seeFig. 1). This video demonstrates the case of a 70-year-old woman with a 100×40-mm LAPC. Preoperative computed t