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Also, cellular type-specific Tslpr gene removal or diphtheria toxin-mediated deletion of specific cellular kinds, revealed that CD11c+ cells excluding Langerhans cells had been accountable for the Oxarol-mediated GC reactions. These outcomes indicate that active vitamin D3 is actually able to enhance the humoral response via Tslp induction in skin and serves as an innovative new vaccine adjuvant. © The Japanese Society for Immunology. 2020