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Embase, Cochrane Library, and MEDLINE/PubMed databases had been looked for trials posted by January 7, 2020, that reported the efficacy and safety of denosumab in patients with giant cellular tumors of bone tissue. .0001). No treatment-related deaths occurred in the assessed scientific studies. Collective research supports the inclusion of surgery to optimal medical treatment with denosumab to cut back cyst dimensions, medical symptoms, and death among patie