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Serum PD-L1 levels had been notably greater in PD-L1 good team compared to PD-L1 negative group (p=0.0158). CONCLUSIONS Our large cohort study indicated that PD-L1 expression in disease cells was related to a poor clinical outcome and vascular development in HCC clients. Furthermore, combination of PD-L1 phrase with tumor-infiltrating CD8-positive T cell status enabled further classification of clients according to their medical outcome. Therefore, PD-L1 phrase in cancer cell