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5) compared to baseline in the OR group only (P = .004 and .01, respectively). Serum cortisol concentration was significantly decreased at D4 and D8 for both groups (maximum decrease, -1.2 ± 0.3 μg/dL; 95% CI, -1.9; -0.6 at D4 for NE group and -2.2 ± 0.3 μg/dL; 95% CI, -2.8; -1.6 at D8 for OR group; P  .001). Oral, but not nebulized dexamethasone is an effective therapy for horses with severe asthma and both treatment modalities inhibit the hypothalamic-pituitary-adrenal axis. Oral, but not nebulized dexamethasone is an effective therap