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We determined pH, morphological parameters of different parts of the digestive canal, and morphometric parameters of the stomach. The addition of prebiotic inulin to calves' diet causes the increase of pH in rumen, abomasum, and intestines but when inulin was added to S. cerevisiae, pH decreased and was even lower than in the control group. Prebiotic inulin and its synbiotic with yeast S. cerevisiae positively impact the development of almost all morphological structures of rumen saccus dorsalis, rumen saccus ventralis, and intestine;