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The manifestation for the carcinogenic aftereffect of pesticides might be decided by the variation of genetics encoding chemical, including PON1 Q192R and GSTM1. The purpose of this research would be to determine polymorphism of PON1 Q192R and methylation of p16 gene promoter, and their particular correlation on Javanese farmers in the agricultural section of Ngablak Subdistrict, Magelang Regency, Central Java. Seventy-eight pesticide-exposed farmers signed up for the study. Po