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s consistent across the full range of SDB severity. Future research should focus on the extent to which CReSS reduces the discrepancy between the apnea-hypopnea index and the respiratory event index, and the ability of CReSS to identify REM sleep-related obstructive sleep apnea. The review aimed to identify the factors influencing adherence to oral appliance therapy in adults with obstructive sleep apnea. The protocol was initially registered with the International Register of Systematic Reviews (Prospero CRD42019122615) prior to undert